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Fluorine amide - derivatives having an inhibitory activity against human leukocyte elastase.
Fluorine amide - derivatives having an inhibitory activity against human leukocyte elastase.
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机译:氟酰胺-对人白细胞弹性蛋白酶具有抑制活性的衍生物。
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摘要
The present invention relates to certain fluoro-amide derivatives, of the general formula CHEM which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these fluoro-amide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.
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