VACCINES AGAINST SEPTICEMIC BACTERIA, PREPARATIONS OF ANTIGENS OF SEPTICEMIC BACTERIA, NOVEL BACTERIA AND VECTORS FOR THE PREPARATION OF SUCH ANTIGENS OR VACCINES

摘要

The bacteria expressing iron-regulated outer membrane proteins of which certain are siderophore or transferrin receptors can be used in a vaccinal preparation. Said bacteria are obtained from a culture in a medium in which the iron content is reduced to a level for obtaining an increased expression of said proteins, and in particular of receptors, sufficient to induce, when said bacteria are used in a vaccine, the formation of antibodies preventing the specific recognition of siderophores by their receptors.