New method of preparation of imidazo (benzothiazoles 2,1 - b) and their salts, the new products obtained, the application as medicinal products, these novel products and the pharmaceutical compositions containing them,

摘要

The invention relates to a new process for the preparation of the products i: & br / (see appended drawing in bopi) & br / in which r1 is cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, r2 and r3 represent: & br / (see appended drawing in bopi) & br / with m = 1, 2 or 3, x1 and x2 = h, alkyl, alkoxy (c1 - 5), and aralkoxy, aryloxy, halogen, nitrile, an azido or x1 and x2 form a methylenedioxy, as well as their addition salts with acids, characterized in that it is reacted with a product of formula ii: & br / (see appended drawing in bopi) & br / with the n, n '- carbonyldiimidazole were then with the hydrochloride is - dimethylhydroxylamine and then with a grignard reagent r1 - mg - hal. / p & & p & the products i are useful as medicaments, because of their agonist properties which are opposite the benzothiazepines and their properties tranquilizing.