Staple and semi-staple oligonucleotides, process for their preparation and applications

摘要

The present invention relates to staple or semi-staple oligonucleotides useful, in particular, for pharmacological purposes, as antisense molecules or for cosmetological or diagnostic purposes, as well as the methods for obtaining such molecules. The staple and semi-staple oligonucleotides that are the subject of the present invention are oligonucleotide-type molecules whose 3 'end or both 3' and 5 'ends are engaged in intra-molecular hydrogel bonds between base pairs. complementary. These molecules, therefore, have increased resistance to exonuclease attacks and can act as an antisense factor with greater durability than the corresponding nuclear oligonucleotides.