Characterization and method of isolation of factor J, an inhibitor of complement C1

摘要

A purified protein, factor J, which has inhibitory properties which prevent the formation or the dissociation of Cl complex and a method of purification for said protein. The method including the following sequential chromatography steps: anion exchange, QAE-"SEPHADEX", heparin- "SEPHAROSE" affinity, "MONO Q" and hydroxylapatite.