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LPS-containing analgesics and veterinary analgesics
LPS-containing analgesics and veterinary analgesics
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机译:含LPS的止痛药和兽用止痛药
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摘要
An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED.sub.50 is 0.4-100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0% in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100% is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and a method of treating pain of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the pain of said animal.
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机译:一种止痛组合物,其包含有效量的至少一种脂多糖,其巨噬细胞活化ED 50为0.4-100 ng / ml培养液,在乙状结肠曲线上观察到其curve测试阳性脂多糖含量,方法是通过测定LPS激活体外培养的巨噬细胞的TNF生产力的能力,并沿纵坐标绘制巨噬细胞激活能力(%),其中在对应于TNF量的情况下,该能力估计为0%巨噬细胞未添加LPS产生的巨噬细胞产生的TNF,并且赋予巨噬细胞激活能力100%,该激活能力提供了最大和恒定量的巨噬细胞产生的TNF,并沿横坐标轴绘制了LPS的test试验阳性LPS含量与药学上或兽医学上可接受的载体混合的对数标度,以便当施用于动物时,可防止所述动物的高胆固醇水平或治愈和一种治疗动物疼痛的方法,包括向所述动物施用一定量的上述组合物,以有效地预防或治疗所述动物的疼痛。
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