Phase transfer catalytic process for preparing intermediates of atenolol, propranolol, and their derivatives

摘要

A phase transfer catalytic process for the preparation of epoxide and halohydrin intermediates, which can be subsequently and directly reacted with isopropylamine to produce beta-adrenergic antagonists such as atenolol, propanolol and their derivatives. In the process disclosed in the present invention, quaternary ammonium salts of high alkyl groups or tertiary ammonium salts of lower alkyl groups are used as catalyst in the phase transfer catalytic oxygenated-alkylation reaction between an aromatic alcohol such as p-hydroxyphenyl acetamide (for the production of atenolol) or &agr;-naphthol (for the production of propranolol) and epichlorohydrin to yield epoxide and halohydrin intermediates. The quaternary ammonium salts of high alkyl groups are represented by the following formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub. 4 are C.sub.1 to C.sub.20 alkyl groups and at least one of the R.sub.1, R. sub.2, R.sub.3, or R.sub.4 is a C.sub.9 to C.sub. 20 alkyl group, and X is a halide group. And the tertiary ammonium salts of lower alkyl groups are presented by the following formula: ##STR2## wherein R.sub.5 is a C.sub.1 to C.sub.20 alkyl group, H is hydrogen, and X is a halide group.