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Laser-induced ablation of atherosclerotic plaque
Laser-induced ablation of atherosclerotic plaque
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机译:激光诱导的动脉粥样硬化斑块消融
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摘要
A method of ablating atherosclerotic plaque by means of short- duration laser light pulses. A carotenoid, such as beta-carotene, is preferably administered to the patient by injection or ingestion prior to exposing the plaque with laser light. Research data obtained by analysis of the absorption characteristics of plaque and the healthy arterial tissue reveals that the plaque may be selectively ablated without damaging the surrounding normal tissue by illuminating the plaque with laser light having a wavelength of about 430 to about 510 nanometers such that the relative absorption coefficient exhibited by the plaque is more than 1.5 times the absorption coefficient of the arterial tissue. Short duration laser light pulses preferably illuminate the plaque for less than the thermal relaxation time of the volume of exposed material. The intensity of the laser light is preferably in the range from about 1 to about 9 joules/cm.sup.2 in order to ablate the plaque without endangering the surrounding tissue. The carotenoid administered to the patient enhances the absorption coefficient of the plaque to facilitate ablation and additionally facilitates the detection of the plaque.
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机译:一种通过短时激光脉冲消融动脉粥样硬化斑块的方法。在通过激光暴露斑块之前,优选通过注射或摄入向患者施用类胡萝卜素,例如β-胡萝卜素。通过分析斑块和健康动脉组织的吸收特性而获得的研究数据表明,通过用波长约430至510纳米的激光照射斑块,可以选择性地消融斑块而不损害周围的正常组织。斑块表现出的相对吸收系数大于动脉组织吸收系数的1.5倍。短持续时间的激光脉冲优选照亮斑块的时间少于所暴露材料体积的热弛豫时间。激光的强度优选在约1至约9焦耳/ cm 2的范围内,以便消融斑块而不危及周围组织。给患者施用的类胡萝卜素增强了斑块的吸收系数,以促进消融并且另外促进了斑块的检测。
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