HUMAN INTERFERON BETA2A AND HUMAN INTERFERON BETA2B, VECTOR CONTAINING GENE ENCODING THE INTERFERON, CELL LINE PRODUCING THE INTERFERON, AND USE OF THE INTERFERON AS MEDICAMENT

摘要

PURPOSE: To obtain a DNA for a recombinant vector for transforming a cell line to the cell line capable of producing human interferon useful as a medicament against growth or differentiation of cells, especially differentiation or the like of last stage cancer cells. ;CONSTITUTION: This DNA is a cDNA having a nucleotide sequence of the formula, and includes the nucleotide sequence coding for human interferon ₂A having 212 amino acids. The ORF of 212 amino acids for producing 23,500 dalton protein is obtained by constructing IFN-₂AE20 cDNA obtained by fusion of cDNA clone A341 and E474 hybridizing with mRNA to be translated to IFN-₂, and determining the nucleotide sequence of the IFN-₂ cDNA.;COPYRIGHT: (C)1995,JPO