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Oxygen displacement derivative null of the nucleophilic reagent - nitrogen oxide addition product as a nitrogen oxide donor professional
Oxygen displacement derivative null of the nucleophilic reagent - nitrogen oxide addition product as a nitrogen oxide donor professional
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机译:亲核试剂的氧置换衍生物无效-作为氮氧化物供体的氮氧化物加成产物
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摘要
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular disorders with the compounds. The active components of the pharmaceutical compositions are compounds of formula I IMAGE wherein R1 and R2 are independently chosen from straight chain and branched chain alkyl and olefinic groups, which may be unsubstituted or substituted; or R1 and R2 together with the nitrogen atom they are bonded to form a heterocyclic group; and R3 is a pharmaceutically acceptable organic group selected from alkyl and olefinic groups which may be unsubstituted or substituted, acyl, a sulfonyl, sulfinyl, sulfenyl, carbonate, or carbamate derivative; or R3 is a group of the formula-(CH2)nONN(O)NR1R2, wherein n is 2-8, and R1 and R2 are as described above. Novel compounds are disclosed wherein at least one of R1, R2 and R3 is an olefinic group or heteroatom-substituted straight or branched chain alkyl or olefinic group. Novel methods of synthesizing the compounds are also disclosed.
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机译:公开了具有抗高血压性质的心血管活性化合物,以及包含这些试剂的药物组合物以及用所述化合物治疗心血管疾病的方法。药物组合物的活性成分是式I 的化合物,其中R1和R2独立地选自直链和支链的烷基和烯基,它们可以是未取代的或取代的; R 1和R 2与氮原子一起键合形成杂环基。 R3是选自烷基和烯基的药学上可接受的有机基团,其可以是未取代的或取代的,酰基,磺酰基,亚磺酰基,亚磺酰基,碳酸酯或氨基甲酸酯衍生物;或R 3为式-(CH 2)n ONN(O)NR 1 R 2的基团,其中n为2-8,且R 1和R 2如上所述。公开了新颖的化合物,其中R 1,R 2和R 3中的至少一个是烯基或杂原子取代的直链或支链烷基或烯基。还公开了合成化合物的新方法。
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