NEW MATERIAL:The compound of formula I [R1 is lower alkoxy, lower alkylthio, etc.; R2 is di(lower alkyl)amino, morpholino, etc,; R3 is H or lower alkoxycarbonyl; R4 is lower alkylthio, halogen, etc.] or its salt. EXAMPLE:8-Chloro-4-(1-oxidothiomorpholino)-2-piperazinopyrido-[3,2-d]p yrimidine. USE:An antithrombotic agent, thrombolytic agent or their intermediate. PREPARATION:For example, a 2,4,8-trihalogenopyrido[3,2-d]pyrimidine of formula II (R3 is alkoxycarbonyl; X is halogen) is used as a starting raw material, made to react with a dialkylamine of formula R2H in a solvent at -50-+50 deg.C for 10-120min and reacting the resultant compound of formula III with an alkali metal salt of a lower alkyl alcohol, etc., in a solvent.
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机译：新材料：式I的化合物[R 1为低级烷氧基，低级烷硫基等。 R 2为二（低级烷基）氨基，吗啉代等。 R 3为H或低级烷氧羰基; R 4为低级烷硫基，卤素等]或其盐。实施例：8-氯-4-（1-氧化硫代吗啉代）-2-哌嗪子吡啶基-[3，2-d] p嘧啶。用途：抗血栓形成剂，血栓溶解剂或其中间体。制备：例如，将式II的2,4,8-三卤代吡啶并[3,2-d]嘧啶（R 3为烷氧羰基; X为卤素）用作起始原料，使其与二烷基胺反应在溶剂中，在-50- + 50℃下，将式R 2 H的式（R 2 H）反应10-120分钟，并使式III的化合物与低级烷基醇的碱金属盐等反应。
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