Production manner null of the substrate, and the substrate in order to do the analysis manner and that manner of nuclear acid base

摘要

A method for analysing sequences of nucleic acids entails the liquid sample which contains denatured nucleic acid being contacted with a light-reflecting support surface which has, chemically bonded to this surface, a nucleic acid strand of defined sequence, where complementary sequences of the denatured nucleic acid in the sample combine by hybridisation with the nucleic acids immobilised on the support, and the thickness of growth of the organic layer forming thereby on the support surface is determined by comparison ellipsometry measurement or the change in the interference patterns on the bilayer reflecting surface. IMAGE