Blood platelet cohesion suppression and the thrombus symptom remedy medicine null which designate the component of the Magnolia salicifoliums as the

摘要

PURPOSE: To prepare an inhibitor of blood platelet aggregation and a therapeutic agent for thromboembolism comprising an ingredient of Magnolia kobus DC. as an active ingredient. CONSTITUTION: This inhibitor of blood platelet aggregation or therapeutic agent for thromboembolism comprises a compound represented by formula I (A is an aromatic group having a lower alkyl or a lower alkoxy as a substituent group or formula II; R1 is a lower alkoxy; R2 and R3 are each H or allyl; R4 is H or a lower alkoxy) or formula III (A is an aromatic group having a lower alkoxy as a substituent group) which is an ingredient of Magnolia kobus DC., e.g. denudatin B, veraguensin or fargesone as an active ingredient. The compounds are obtained by drying the Magnolia kobus DC. which is a Chinese medicine or drying, then pulverizing or powdering the dried Magnolia kobus DC., partitioning and extracting the resultant pulverized or powdery material with alcohols, ketones, chloroform, etc., or a mixed solvent thereof, distilling off the organic solvent from the prepared organic layer under a reduced pressure, treating the residue by silica gel chromatography and concentrating the resultant fraction eluted with the single or the mixed solvent.