NEW POLYPEPTIDE, ITS PRODUCTION, DNA CAPABLE OF CODING THE SAME POLYPEPTIDE, VECTOR COMPOSED OF THE SAME DNA, HOST CELL TRANSFORMED BY THE SAME VECTOR, ANTIBODY AGAINST THE SAME POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME POLYPEPTIDE OR ANTIBODY

摘要

PURPOSE:To obtain a new polypeptide, comprising a specific amino acid sequence, having biological activities concerned in survival and proliferation of a hematopoietic stem cell and useful for preventing and treating inflammatory diseases, deficiency in the hematopoietic stem cell after the bone marrow transplantation, leukemia, etc. CONSTITUTION:This polypeptide is composed of an amino acid sequence expressed by sequence table I which is in a substantially pure form, its homolog, its fragment or a homolog of the fragment. Furthermore, the polypeptide is obtained by culturing a host cell transformed by an expression vector composed of a DNA capable of coding the polypeptide under conditions for expressing the polypeptide.