AGENT FOR INDUCING PRODUCTION AND SECRETION OF NERVE GROWTH FACTOR CONTAINING SUBSTITUTED 1,4-NAPHTHOQUINONE DERIVATIVE AS ACTIVE COMPONENT

摘要

PURPOSE: To obtain an agent for inducing the production and secretion of nerve growth factor(NGF), exhibiting remarkable inducing effect at a low concentration and expectable as an agent for the prevention and treatment of various cerebral function disorders and peripheral nerve disorders. ;CONSTITUTION: The agent for inducing the production and secretion of NGF contains a substituted 1,4-naphthoquinone derivative of the formula [R₁ to R₄ are H, halogen or (substituted)alkyl or alkenyl; X₁ and X₂ are OH which may be esterified or etherified], e.g. 5,8-dihydroxy-1,4-naphthoquinone or 2,3- dichloro-5,8-dihydroxy-1,4-naphthoquinone, as an active component. The diseases to be treated or prevented by this agent for inducing the production and secretion of NGF are ischemic cerebral diseases, Alzheimer's disease, diabetes, familial dysautonomia, neurofibromatosis, neuroblastoma, chromaffinoma, etc.;COPYRIGHT: (C)1994,JPO