BONE ABSORPTION INHIBITING SUBSTANCE, BR-040 AND BR-042

摘要

PURPOSE: To obtain a novel bone absorption inhibiting substance having an excellent bone absorption inhibiting ability, useful as a therapeutic agent for diseases derived from the bone metabolism abnormality such as osteoporosis, high calcium disease, or the like. ;CONSTITUTION: A compound represented by the formula, for example, BR-40 which is a substance having the following properties; elemental analysis experimental value (%): C-60.25, H-7.52, O-27.75, N-2.49; elemental analysis theoretical value (%): C-61.35, H-7.72, O-28.28, N-2.75; molecular formula: C₂₆H₃₇NO₈.H₂O; molecular weight: 491; melting point: 73 to 76°C; solubility: soluble in chloroform, methanol, or the like, slightly soluble in n-hexane and benzene, and insoluble in water; color reactions: positive to I₂, H₂SO₄, negative to ninhydrine and FeCl₃; classification among basic, acidic, and neutral; neutral. The compound is obtained by culturing Streptmyces-hydroscopicus-var. ossamyceticus-TA-0247 (FERM-P-13923), which is a novel microbe in an aerobic condition and refining and separating from the culture solution.;COPYRIGHT: (C)1995,JPO