DIASTEROISOMER MIXTURE USEFUL AS ODORANT

摘要

PURPOSE: To provide a diasteroisomer mixture comprising a specific isomer mixture which has the same perfume as conventional excellent odorant mixtures and is excellent in economical efficiency where the diasteroisomer in pure form is effective in a very small amount. ;CONSTITUTION: This 7R/7S-diasteroisomer mixture of formula I in pure form can be obtained by reacting 1,1,2,3,3-pentamethylindane of formula II with S(-)- propylene oxide of formula III in a solvent such as a halogenated hexane with the use of a Lewis acid such as AlCl₃ to obtain a 2R/2S-diasteroisomer mixture of formula IV and then, subjecting this 2R/2S-diasteroisomer mixture to isochroman ring closure in the presence of a protonic acid catalyst such as p-toluenesulfonic acid with the use of formaldehyde or the like.;COPYRIGHT: (C)1995,JPO