PREPARATION OF N-ACETYL HOMOCYSTEINE THIOLACTONE FROM DL-HOMOCYSTINE BY ELECTROCHEMICAL METHOD

摘要

PURPOSE: To prepare the compound usable for the therapy of liver complaints and as a mucolytic. ;CONSTITUTION: An aqueous solution of DL-homocysteine and a mineral acid are submitted to electrolysis in an electrolytic cell as the catholyte with anolyte of any saline aq. solution separated. The electrodes are flat, or three- dimensional, forming a compact or fluidized bed. The current tension is 10mA/cm² to 2A/cm² and the temperature is 0 to 90°C. The solution obtained in the catholyte is concentrated, dried and acetylated to obtain the N-acetyl homocysteine thiolactone of formula I with a high degree of purity.;COPYRIGHT: (C)1995,JPO