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Phenoxyethylaminderivater and pharmaceutically acceptable salts thereof, the preparation of these compounds and pharmaceutical composition containing the compounds
Phenoxyethylaminderivater and pharmaceutically acceptable salts thereof, the preparation of these compounds and pharmaceutical composition containing the compounds
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机译:苯氧乙基麻醉剂及其药学上可接受的盐,这些化合物的制备以及含有该化合物的药物组合物
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摘要
This invention provides a group of hydroxycycloalkanephenoxyethylamine antidepressant derivatives of the following structural formula: IMAGE in which R1 is hydrogen or alkyl of 1 to 6 carbon atoms; R2 is alkyl of 1 to 6 carbon atoms; R3 and R4 are independently hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, halo or trifluoromethyl; R5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkanoyl of 2 to 7 carbon atoms; and n is one of the integers 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
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机译:本发明提供了一组具有下列结构式的羟基环烷苯氧基乙胺抗抑郁药衍生物:其中R1是氢或1-6个碳原子的烷基; R 2为1-6个碳原子的烷基; R3和R4独立地是氢,羟基,1-6个碳原子的烷基,1-6个碳原子的烷氧基,2-7个碳原子的烷酰氧基,卤素或三氟甲基。 R5是氢,1-6个碳原子的烷基或2-7个碳原子的烷酰基; n是0、1、2或3的整数之一;或其药学上可接受的盐。
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