New N-aryl and N--heteroarylamide and urea derivatives as inhibitors of acyl-coenzyme A: cholesterol acyltransferase

摘要

Compounds of the formula CHEM the pharmaceutically acceptable salts thereof, wherein Q and R1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.