NOVEL BENZOYL AMINO ACID DERIVS., PHARMACEUTICAL COMPNS. CONTH. THEM AND PROCESS TO PREPARE THEM

摘要

The peroxidation of lipids inhibiting N-benzoylamino acid derivatives of the general formula (I), CHEM wherein R1 and R2 , which are the same or different, stand for a hydroxyl group optionally bearing an acetyl group; or a C1-6alkoxy group optionally substituted by a phenyl group; R3 represents: hydroxyl group; C1-10alkoxy group; or a C1-4alkoxy group optionally substituted by a phenoxy group optionally bearing a nitrogen-containing substituent; or an -NR4R5 group, where R4 and R5, which are the same or different, mean: hydrogen; hydroxyl group; C1-12alkyl group; C1-4alkyl group optionally substituted by a hydroxyl group or an amino group; R4 and R5 together with the adjacent nitrogen form an optionally substituted 5- or 6-membered heterocyclic group optionally containing an additional nitrogen atom, this heterocyclic group optionally being substituted by an oxo group or an optionally phenyl-substituted C1-4alkyl group or C3-5alkenyl group; and when being piperazine, this heterocyclic group may be substituted also by a diaminopyrimidinyl or di(pyrrolidino)-pyrimidinyl group; and n means an integer from 2 to 15 with the proviso that: when R3 means hydroxyl group and n is 5, as well as one of R1 and R2 means a 4-hydroxyl group, then the other one of R1 and R2 is different from a 3-hydroxyl or 3-methoxy group; and when n is 2 or 3, then R1 and R2 cannot simultaneously stand for 2- and 3-methoxy group, as well as their tautomers, racemates and optically active individual (pure) isomers or mixtures thereof and the salts of these compounds and pharmaceutical compositions containing these compounds.