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A method for detecting a retinoblastoma gene defect in tumors using a retinoblastoma gene probe
A method for detecting a retinoblastoma gene defect in tumors using a retinoblastoma gene probe
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机译:一种使用视网膜母细胞瘤基因探针检测肿瘤中视网膜母细胞瘤基因缺陷的方法
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摘要
A Method of and a kit for detecting the predisposition to retinoblastoma. A method for detecting a defect in the retinoblastoma gene in retinoblastoma, osteosarcoma, fibrosarcoma, melanoma, soft tissue sarcoma, small-cell carcinoma and mammary tumors. The method includes hybridizing a retinoblastoma gene probe to DNA extracted from target tissue and then determining binding of the probe to the DNA. The target tissue can be tumor or non-tumor tissue and from a fetus to an adult. Further there are DNA probes of 4.6, 3.8, and 0.9 kb.
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