首页>
外国专利>
Tumor necrosis factor receptor-I associated proteins and protein kinase and methods for their use
Tumor necrosis factor receptor-I associated proteins and protein kinase and methods for their use
展开▼
机译:肿瘤坏死因子受体I相关蛋白和蛋白激酶及其使用方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides an isolated and purified protein that associates with the cytoplasmic domain of the p60 form of the tumor necrosis factor receptor, having a molecular weight of about 52-55 kDa on SDS-PAGE, is a phosphoprotein, and does not bind to the p80 form of the tumor necrosis factor receptor. Also provided is an isolated and purified protein kinase that binds to the cytoplasmic domain of the p60 form of the tumor necrosis factor receptor, said kinase phosphorylates the p60 form of the tumor necrosis factor receptor. Also provided are various methods of manipulating this tumor necrosis factor receptor-associated protein and kinase in order to reduce various biological effects of tumor necrosis factor.
展开▼