ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES, A PHARMACEUTICAL COMPOSITION, A METHOD FOR INHIBITION OF MATRIX METAL-PROTEINASES OR PRODUCTION OF TUMORS NECROSIS FACTOR AND A METHOD FOR TREATMENT OF DISEASES CAUSED BY MATRIX METAL-PROTEINASES AND TUMORS NECROSIS FACTOR

摘要

A compound of formula (I) wherein R1, R2 and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceralion, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) aad analgesica, and in combination with cytotoxis drugs such as adriamycin, daunomycin, cis-platinjm, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.