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ANTIHERPES PENTAPEPTIDES, THEIR PREPARATION, AND PHARMACEUTICAL ANDCOSMETIC COMPOSITIONS CONTAINING THEM
ANTIHERPES PENTAPEPTIDES, THEIR PREPARATION, AND PHARMACEUTICAL ANDCOSMETIC COMPOSITIONS CONTAINING THEM
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机译:抗菌药五肽,其制备方法以及包含它们的药物和药妆成分
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摘要
Disclosed herein are pentapeptide derivatives of theformula XNR1-CH(R2)-C(O)-NH-CH(R3)-C(O)-NR4-CH(CH2Y)-CO-NH-CH[CR5(R6)-COOH]-C(W)-NH-CH(R7)-Z wherein X is aterminal group, for example, alkanoyl or phenylalkanoyl radicals,R1 is alkyl or phenylalkyl, R2, R3 and R7 are selected from aminoacid or derived amino acid residues, R4, R5, and R6 are hydrogenor lower alkyl, W is oxo or thioxo, Y is carboxy, carbamyl or5-1H-tetrazolyl and Z is carboxy or 5-1H-tetrazolyl. The derivativesare useful for treating herpes infections.
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