Benzokondenserte 5-ringheterocykler, fremgangsmåte for fremstilling derav, deres anvendelse som medikament, deres anvendelse som diagnostikum samt medikament inneholdene disse

摘要

There are described benzo-fused 5-membered ring heterocycles of the formula I IMAGE where X is N or CR(6); Y is oxygen; A and B together are a bond or are both hydrogen if X is simultaneously CR(6) and Y is NR(7), one of these substituents R(1) to R(6) is a -CO-N = C(NH2)2 group; the other substituents R(1) to R(6) in each case are H, Hal, alkyl; up to two of the other substituents R(1) to R(6) are CN, NO2, N3, (C1-C4)-alkoxy, CF3; up to one of the other substituents is R(8)-CnH2n-Z-, phenyl; R(7) is H, alk(en)yl, R(8)-CnH2n-, and their pharmaceutically tolerable salts. There is further described a process for the preparation of the compounds I, which consists in reacting a compound of the formula II IMAGE wherein one of the substituents R(1)' to R(5)' is a -CO-L group and L is a leaving group which can be readily nucleophilically substituted, with guanidine, and in optionally converting the product to the pharmacologically tolerable salts.