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Transdermal patches for oestradiol admin. - contg. isopropylidene mono- or di-glycerol as penetration enhancer
Transdermal patches for oestradiol admin. - contg. isopropylidene mono- or di-glycerol as penetration enhancer
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机译:雌二醇的透皮贴剂。 -续异亚丙基单或双甘油作为渗透促进剂
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PCT No. PCT/EP94/00670 Sec. 371 Date Feb. 12, 1996 Sec. 102(e) Date Feb. 12, 1996 PCT Filed Mar. 7, 1994 PCT Pub. No. WO94/22481 PCT Pub. Date Oct. 13, 1994An active substance patch releasing estradiol to the skin is characterized by the fact that it consists essentially of a backing layer and an attached active substance reservoir which comprises pressure sensitive adhesive and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, the active substance reservoir being a polymer matrix which-in order to improve the bioavailability of the estradiol-comprises an added penetration enhancer of the general formula: IMAGE wherein R=-CH2OH or -CH2-O-CH2-CHOH-CH2OH.
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