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N-PHENYLALANYL AND N-PHENYLGLYCYL DERIVATIVES OF THE DIPEPTIDE OF L-AZETIDINE-2-CARBOXYLIC ACID AND L-ARGININE ALDEHYDE; ANTI-BLOOD CLOTTING COMPOSITIONS
N-PHENYLALANYL AND N-PHENYLGLYCYL DERIVATIVES OF THE DIPEPTIDE OF L-AZETIDINE-2-CARBOXYLIC ACID AND L-ARGININE ALDEHYDE; ANTI-BLOOD CLOTTING COMPOSITIONS
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机译:L-氮杂环丁烷-2-羧酸和L-精氨酸醛的二肽的N-苯丙氨酸和N-苯乙炔基衍生物;抗血凝成分
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摘要
Thrombin inhibitors represented by the formula CHEM as provided wherein A is e.g. phenylglycyl, and phenylalanyl, a-methylphenylalanine and a-methylphenylglycine wherein the amino group is preferably substituted with lower alkyl alkanoyl or lower alkoxycarbonyl, or a bicyclo group e.g. 1,2,3,4-tetrahydroisoquinolin-1-yl. Also provided are a method for inhibiting clot formation in man and animals, pharmaceutical formulations useful in the method and intermediates for the inhibitors.
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