AGENTS FOR FIGHTING AGAINST INTERNAL PARASITES, METHOD OF OBTAINING SUCH AGENTS AND METHOD OF INCREASING EFFECTIVENESS OF CYCLIC DEPSIPEPTIDES

摘要

Endoparasitic activity of cyclic depsipeptides (I) comprising amino acid and hydroxycarboxylic acid units and having 6-30 ring atoms is increased by praziquantel (II) and epsiprantel (III). An endoparasitic agent contg. (I) together with (II) and (III) is also claimed. Known cpds. (I) are disclosed in EP382173 (depsipeptide PF 1022), WO9319053, J. Antibiotics 45 (1992) pp. 1207-1255 and pp 1273-1277, Helv. Chimn. Acta 46 (1963) pp 927-935 and pp 1715-1720, ibid, 47 (1964) pp. 166-173, Tetrahedron Letters 2 (1971) pp. 159-162, Biochem. Biophys. Res. Commun. 57 (1974) pp. 554-561 and Zh. Obshch. Khim. 41-(10) (10972) pp. 2320-2334. (II) is known from GB1441554 and (II) is known from EP134984 and EP185012.