N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYLCOENZYME A:CHOLESTEROL-ACYLTRANSFERASE, PHARMACEUTICAL PREPARATIONS CONTAINS THESE COMPOUNDS AND USE

摘要

PCT No. PCT/US93/03539 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Apr. 20, 1993 PCT Pub. No. WO93/24458 PCT Pub. Date Dec. 9, 1993A compound of the formula and the pharmaceutically acceptable salts thereof, wherein R17, R18 and R1 are as defined below. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.