Process for the preparation of 4-demethoxydaunomycinone, the aglycone of 4-demethoxy-daunorubicin

摘要

4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4- demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4- demethyl-daunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound with an amine, removing the amino protecting group from the resultant 4-demethyl-4-(protected amino)-13-dioxolanyl- daunomycinone, diazotizing the thus-freed 4-amino group and reducing under mild conditions the resulting diazonium compound.