1 - (2 - methyl) - 1 - 3 - oxo - rodanidopropyl - proline and a process for the production of 1 / (2s) - 2 - mercapto - methyl - 1 - 1-oxopropyl / - l - proline

摘要

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). IMAGE (I) which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) IMAGE (II) in an inert solvent, in the presence of a catalyst, at a temperature of 50 DEG to 120 DEG C. under a pressure of 105 to 107 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). IMAGE (III)