SUBSTITUTED DIHYDROISOCHINOLINONES AND RELATED COMPOUNDS AS AMPLIFIERS OF THE LETAL EFFECTS OF RADIATION AND CERTAIN CHEMOTHERAPEUTICS; SELECTED CONNECTIONS, ANALOGA AND METHOD.

摘要

The invention is selected, novel, and known analogs of isoquinolinones of the formula CHEM and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.