PROCEDURE FOR THE MANUFACTURE OF 2-(3-PYRIDYL)- TETRAHYDROTHIOPYRAN-2-carboxylic acid THIOAMID-1- (1R,2R)OXYDES, 2-(3-PYRIDYL)- TETRAHYDROTHIOPYRAN-2-CARBOTHIOAMID-1- (1R,2R)OXYDE AND THEIR PHARMACEUTICAL SUBSTANCES.

摘要

Process for preparing (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides of general formula: IMAGE (R1=alkyl containing 1 to 4 carbon atoms), by the action of an alkyl isothiocyanate on the 1R,2R and 1R,2S sulphoxides of formulae: IMAGE IMAGE employed alone or mixed, the (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides thereby obtained and pharmaceutical compositions containing them. (1R,2R)-2-(3-Pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides are especially useful as antihypertensives.