phenylethanolamino and phenylethanolaminomethyltetraline, procedures in the manufacture of intermediates thereof and pharmaceutical compositions containing them.

摘要

Phenylethanolamino- and phenylethanolaminomethyl-tetralins of formula (I) IMAGE in which X represents a hydrogen atom, a halogen atom, a (C1-C4)alkyl group or a trifluoromethyl group, A represents a bond between the group -COOR and the tetralin ring, a (C1-C4)alkylene group or a (C2-C4)alkenylene group, R is a hydrogen atom or a (C1-C4)alkyl group, and n is 0 or 1 and their salts, are prepared, for example, by reaction of an epoxide of formula (IIa) IMAGE with a tetralin of formula (III) IMAGE in which A and n are as defined above and R' is a (C1-C4)alkyl group, if appropriate followed by a basic hydrolysis to give the compounds (I) where R is hydrogen. The novel compounds have very advantageous properties as antidepressant agents and intestinal spasmolytics. The novel intermediates of formula (III) are also claimed.