Process for obtaining 2,6-dimethyl-4- (2-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate 3-isobutyl-5-methyl.

摘要

NEW METHOD FOR OBTAINING 2,6-dimethyl-4- (2 '' - nitrophenyl) -3,5-pyridinedicarboxylate 3-isobutyl-5-METHYL VERIFIED in four steps. Isobutyl acetoacetate OBTAIN FROM 2,2,6-trimethyl-1,3-dioxen-4-one and isobutanol. PREPARATION isobutyl-3-aminocrotonate FROM isobutyl acetoacetate ammonium acetate. OBTAINING THE benzylidene derived from acetoacetate and benzaldehyde accordingly. DERIVATIVE benzylidene condensation with 3-aminocrotonate in the presence of activated alumina to give the dihydropyridine derivatives. Advantages obtained by this method REGARDING THE PREVIOUS STATE OF THE ART: A) PROCESS CONDITIONS MADE IN RAPID SOFT AND SIMPLE, yielding HIGH QUALITY PRODUCTS. B) THE LAST STEP IS DONE solid phase, DIHYDROPYRIDINES TRACES OF AVOIDING symmetrical. C) OBTAINING dihydropyridine solventless MINIMAL PRODUCTION WASTEWATER CONTAMINATION. D) O ACIDS USING RECYCLED CATALIZADORESBASICOS. E) LOW COST OF PROCESSES AND WASTE MINIMIZATION REACTIVOS. F) low environmental impact.