Method for obtaining new arene (e) indoles useful as intermediates in the synthesis of products with antitumor activity.

摘要

NEW PROCEDURE FOR OBTAINING ARENOL [E] INDOLES useful as intermediates in the synthesis of products with antitumor activity. Comprising: (A) reacting (VI) with a strong base and then with an aldehyde Ar-CHO to give (VII); (B) oxidizing (VII) to give the ketone (VIII); (C) reacting (VIII) with a strong base and then with an acyl chloride CLCOR to give (IX); (D) cyclizing PHOTOCHEMISTRY (IX) to give (I). In these formulas Ar represents phenyl or substituted phenyl; AR 'represents a radical (I) (II) or (III); R represents an acyl group, AR '' it represents 4-methoxycarbonyl-N-methoxymethyl-2-pyrryl, 4-methoxyphenyl or 3,4,5-trimethoxyphenyl. The compounds (I) are useful as intermediates in the synthesis of HEXAHIDROARENO [E] CIDOPROPA [C] indole-4-ONES WITH AN ACTIVITY TITUMORAL.