Intermediate for the synthesis of lansoprazole and its method of obtention.

摘要

Intermediate for the synthesis of lansoprazole and process for obtaining them. CHEMICAL FORMULA (I), called N-oxide, 2 - [[[1H-benzimidazol-2-yl] thio] methyl] -3-methyl-4- (2,2,2-trifluoroethoxy) pyridine, used as INTERMEDIATE for the synthesis of pharmaceutically active agent, antiulcer and commercial CALLING lansoprazole. METHOD FOR PREPARING (I) from the N-OXIDE 2,3-dimethyl-4-nitropyridine. PRODUCT USE PROCEDURE (I) as intermediate in the synthesis of lansoprazole wherein the N-oxide group pyridine (I) IS REDUCED BY A pyridyl phosphorus trichloride in chloroform or DIMETILFORMANIDA, GIVING 2 - [[[3- METHYL-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] thio] -1H-benzimidazole, and because this is oxidized to LANSOPRAZOL BY hYDROPEROXIDE tert-butyl in the presence of vanadium compound as catalyst. The invention is useful for industrially obtained lansoprazole pure and higher performance FORM.