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Liposomal polyene preliposomal powder and method for its preparation.

机译:脂质体多烯脂质体前体粉末及其制备方法。

摘要

It DESCRIBES A METHOD FOR STABLE PREICO prepare a powder which when hydrated with water or a SALINE, forms a liposome solution CONTAINING MEDICINAL a polyene, such as nystatin. The method requires the steps of: COMBINING AT LEAST A phospholipid with a first organic solvent to form a first solution; ADD AN AMOUNT WATER Clarifying the first solution; COMBINING a polyene with a second organic solvent to form a second solution; Combine the first and the second solution to produce a solution substantially clear, and then remove ORGANIC SOLVENTS, LEAVING THE DUST.
机译:本发明描述了一种用于制备稳定的preico的方法,该粉末与水或盐酸盐水合时形成包含多烯的药物如制霉菌素的脂质体溶液。该方法需要以下步骤:至少使磷脂与第一有机溶剂结合以形成第一溶液;加水澄清第一个解决方案;将多烯与第二有机溶剂合并以形成第二溶液;合并第一溶液和第二溶液以产生基本透明的溶液,然后除去有机溶剂,除掉灰尘。

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