Process for manufacturing enantiomerically pure -benzoic acid 4- (4- (4'-tert. Butylphenyl) -2-hydroxybutoxy) and its alkyl ester.

摘要

Obtaining a pure enantiomers OF LIFIBROL and its alkyl esters, yielding surprisingly good, it is achieved by the transformation of forms enantiomeric Pure S (-) XIBUTANO ester acid alkyl 4 ELEVATED TEMPERATURE IN DMF, AND PRESENCE OF eSTER acid alkyl 4 HALF recrystallization, RECOVER ester LIFIBROL PURO stereochemical, OR OCCUR THROUGH saponification AND MILD ALKALINE acidifications, enantiomer LIFRIBOL FOLLOWING IN PURE AND HASTY crystalline form.