METHOD AND COMPOSITION FOR THE TREATMENT OF APATHY-AMOTIVATION SYNDROME

摘要

In accordance with the present invention, neuropsychiatric symptoms of apathy-amotivation syndrome and particularly those symptoms in: Alzheimer's disease, multiple sclerosis, Huntington's chorea, frontal lobe lesions, and AIDS dementia can be ameliorated by treating a patient with a histamine H2-antagonist that passes the blood-brain barrier. Suitable H2-antagonists include famotidine and ranitidine. The H2-antagonists may be co-administered with other compounds which are known to be useful in the treatment of the above neuropsychiatric conditions, and in one aspect of the invention can be formulated with such other compounds into a therapeutic composition.