16-hydroxytriptolide composition and method for immunotherapy

摘要

A composition for use in immunosuppression therapy is disclosed. The composition includes an immunosuppressant drug, such as cyclosporin A and an amount of 16-hydroxytriptolide effective to potentiate the immunosuppressive effect of the immunosuppressant drug. The composition is particularly useful for in treating transplantation rejection or autoimmune disease. Also disclosed is a method of immunosuppression that includes administering to a subject (i) a pharmaceutically effective amount of an immunosuppressant drug and (ii) purified 16-hydroxytriptolide in an amount effective to potentiate the action of the drug.