MONOCLONAL ANTIBODIES AGAINST LEUKOCYTE-SPECIFIC G-PROTEIN-COUPLED RECEPTORS

摘要

Monoclonal antibodies against leukocyte-specific G-protein-coupled receptors (L-GCR) are disclosed. These antibodies may be produced by the following steps: (a) introduction of a L-GCR coding nucleic acid into cells and expression of L-GCR; (b) immunisation of animals with L-GCR-expressing cells (a); and (c) fusion of spleen cells from the immunised animals (b) with myeloma cells and production of monoclonal L-GCR antibody-producing hybridoma cells. Also disclosed is a process for producing such antibodies, their use and kits containing the same, as well as a process for producing monoclonal GCR antibodies.