Plasmids containing a chicken beta-actin promoter and a human factor VIII:C gene, transformants and processes for preparing human factor VIII:C

摘要

A plasmid for the expression of a protein having the bio­logical activity of human factor VIII:C is described, which comprises a chicken β-actin promoter or a derivative thereof and downstream of the promoter a gene coding for said protein having the biological activity of human factor VIII:C. Furthermore, the corresponding transformed micro­oganisms and processes for the production of a protein having the biological activity of human VIII:C are described. The plasmids allow the production of protein having the biological activity of human factor VIII:C with a high efficiency in an industrial scale.