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Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
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机译：使用渥曼青霉素及其类似物抑制骨质流失和软骨降解的方法
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摘要
Wortmannin and certain of its analogs are inhibitors of bone loss/bone resorption and cartilage degradation. Use of the following compounds wherein R is hydrogen or acetoxy, and R' is C₁-C₆ alkyl; wherein R'' is hydrogen, C₁-C₆ alkyl or wherein R''' is hydrogen or C₁-C₆ alkyl; wherein R¹ is hydrogen, methyl, or ethyl; and R² is hydrogen or methyl; or a pharmaceutically acceptable salt of any of the above.
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机译：Wortmannin及其某些类似物是骨质流失/骨吸收和软骨降解的抑制剂。使用以下化合物 <图像文件=“ IMGA0001.GIF” he =“ 55” imgContent =“ chem” imgFormat =“ GIF” wi =“ 94” /> 其中R为氢或乙酰氧基，R′为C1-C4烷基; <图像文件=“ IMGA0002.GIF” he =“ 59” imgContent =“ chem” imgFormat =“ GIF” wi =“ 97” /> <化学id =“ chema03” > <图像文件=“ IMGA0003.GIF” he =“ 57” imgContent =“ chem” imgFormat =“ GIF” wi =“ 97” /> <！-EPO - -> 其中R”是氢，C 1 -C 4烷基或 <图像文件=“ IMGA0004.GIF” he =“ 13” imgContent =“ chem” imgFormat =“ GIF” wi =“ 24” /> 其中R”′是氢或C 1 -C 4烷基; <图像文件=“ IMGA0005.GIF” he =“ 60” imgContent =“ chem” imgFormat =“ GIF” wi =“ 93” /> 其中R 1是氢，甲基或乙基; R 2为氢或甲基;或以上任何一种的药学上可接受的盐。
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