Synthesis of indole by dehydrogenation of indolin (SYNTHESIS OF INDOLES BY DEHYDROGENATION OF INDOLINES)

摘要

Dehydrogenation of indolin or its salt gives the corresponding indole of general formula (I);[Wherein, R^OneAnd R³Independently represent hydrogen or an alkyl group having 1 to 4 carbon atoms, and R²Represents a hydrogen, a methyl group or a carboxyl group, and R⁴And R⁵An amino group, a hydroxy group, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, or when they are bonded to adjacent carbon atoms, R⁴And R⁵Together may represent an alkylenedioxy group having 1 to 4 carbon atoms. According to this method, pure indole can be obtained in high yield.