Indole Derivatives as Steroid 5 Alpha-Reductase Inhibitors as Steroid 5 Alpha-Reductase Inhibitors

摘要

The present invention provides compounds of the general formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing such compounds, their use, methods and intermediates used in their preparation.;Wherein X is O, NH, N (C_One-C₄Alkyl), direct bond, C_One-C₄Alkylene, C₂-C₄Alkenylene or C₂-C₄Alkynylene wherein the alkylene, alkenylene and alkynylene are C_One-C₄/RTI is optionally substituted by alkyl or aryl; Y is methylene; 0 /RTI ₂-C₆Alkylene; C₂-C₆Alkenylene or C₂-C₆Alkynylene wherein all of these groups are C_One-C₆Or a group of the general formula (II) wherein m and n are each independently selected from integers of 0 and 1 to 5, wherein the sum of m and n is not more than 5 And p is an integer from 2 to 6; R is H, OH, halo, C_One-C₄Alkyl or C_One-C₄Alkoxy; R^One, R², R³And R⁴Are each independently H, C_One-C₄Alkyl, C_One-C₄Alkoxy, OH, halo,-CF₃,-CO₂(C_One-C₄Alkyl),-CONH₂,-CONH (C_One-C₄Alkyl) and-CON (C_One-C₄Alkyl)₂/RTI R⁵Is-COOH,-COOR⁷,-CONR⁸R⁹Or tetrazol-5-yl; R⁶Is a group of the above general formula (III) or (IV).