Anti-sense oligodeoxynucleotides and their uses for fibrous cell active materials

摘要

The present invention relates to an anti-sense oligodeoxynucleotide against mRNA of a fibrous cell active substance which is secreted in a large amount at a wound site to promote fibrosis of the tissue. The anti-sense oligodeoxynucleotides according to the present invention inhibit gene expression of these substances by binding to a complementary sequence to mRNA of a fibrous cell active substance such as TGF-beta, TNF-, PDGF, Production of fibrous cell active material and scar formation due to fibrosis of the tissue is prevented so that the wound area has almost the same appearance and elongation strength as normal operation. Thus, the present invention also relates to the use of anti-sense oligodeoxynucleotides as scarring inhibitors for fibrous cell active materials.