METHOD FOR PRODUCING OF HYBRID HUMAN INF-Ñß amp; INF-W

摘要

The invention relates to novel hybrid interferons comprising part of an alpha -interferon and part of an omega-interferon, the N-terminal Met- or N-formyl-Met derivatives of these interferons and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives of these interferons, their use as medicaments and as intermediates for the immunisation of test animals and the preparation of these interferons, novel monoclonal antibodies and their use for the purification of alpha - and omega-interferons, the hybrid cell lines secreting them, and the preparation of these hybrid cell lines, a novel purification procedure for alpha - and omega-interferons with the aid of a novel antibody affinity column containing the abovementioned novel monoclonal antibodies, and the preparation of these antibodies, novel hybrid plasmids for improving the expression of the omega-interferons, and novel intermediate plasmids for preparing the novel plasmids, and their preparation.