Cancer spontaneously transgenic mice and methods for their production

摘要

The present invention relates to a mouse model for transplanting a spontaneously transgenic mouse which induces thymus carcinoma and renal adenoma after transplantation of a gene for SV40 T antigen cancer using a regulator of SV40 early expression site in an F1 hybrid (C57BLxCBA) And a manufacturing method thereof.;The mouse spontaneously transgenic mouse model according to the present invention is used in a method of searching for a linkage between the expression of a cancer gene and a carcinogenic process at an individual level in vivo and searching for a carcinogenic factor, And can be used for the development of a new drug's assay system and therapeutic agent.